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KMID : 0370220230670010032
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Yakhak Hoeji
2023 Volume.67 No. 1 p.32 ~ p.44
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Development and Evaluation of Implant using Hot-Melt Extrusion
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Lee Soo-Hwan
Lee Geun-Nyeong
Kim Young-Jin
Cho Young-Ho
Lee Gye-Won
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Abstract
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In this study, poly(lactic-co-glycolic acid) (PLGA)-based subcutaneous implant containing metformin HCl wasprepared by hot-melt extrusion (HME). This study aimed to evaluate swelling and dissolution behavior for application assubcutaneous implant. Implants containing metformin HCl were fabricated successfully at 30 rpm, 90oC by HME. Drugexcipientcompatibility studies through FT-IR and DSC revealed the absence of any interaction between the drug andpolymers. Dissolution rate and swelling ratio of metformin HCl was significantly affected by the type of PLGA.
Dissolution rate increased as the ratio of -COOH terminal group and GA. By the results, we could confirm that themechanism of drug release from implants is Korsmeyer-Peppas model (n=0.14~0.71) by combination of non-fickiandiffusion and erosion. The formulation F7 with 65% of RG 752H and 5% of RG 502 was showed excellent swelling ratiowith drug release control. In this study, mixing 5~10% of RG 502 with RG 752H can be expected to develop optimalimplants exhibiting diffusion-controlled release for 3 months without initial burst release.
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KEYWORD
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Hot melt extrusion (HME), Implant, Metformin HCl, PLGA, RG 752H, RG 502
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